Accurate Classification of Differential Expression Patterns in a Bayesian Framework With Robust Normalization for Multi-Group RNA-Seq Count Data
نویسندگان
چکیده
منابع مشابه
Differential Expression Analysis for RNA-Seq Data
RNA-Seq is increasingly being used for gene expression profiling. In this approach, next-generation sequencing (NGS) platforms are used for sequencing. Due to highly parallel nature, millions of reads are generated in a short time and at low cost. Therefore analysis of the data is a major challenge and development of statistical and computational methods is essential for drawing meaningful conc...
متن کاملA Hypothesis Testing Based Method for Normalization and Differential Expression Analysis of RNA-Seq Data
Next-generation sequencing technologies have made RNA sequencing (RNA-seq) a popular choice for measuring gene expression level. To reduce the noise of gene expression measures and compare them between several conditions or samples, normalization is an essential step to adjust for varying sample sequencing depths and other unwanted technical effects. In this paper, we develop a novel global sca...
متن کاملTCC: Differential expression analysis for tag count data with robust normalization strategies
The R/Bioconductor package, TCC, provides users with a robust and accurate framework to perform differential expression (DE) analysis of tag count data. We recently developed a multi-step normalization method (TbT; Kadota et al., 2012 [3]) for two-group RNA-seq data. The strategy (called DEGES) is to remove data that are potential differentially expressed genes (DEGs) before performing the data...
متن کاملPackage 'tcc' Title Tcc: Differential Expression Analysis for Tag Count Data with Robust Normalization Strategies
April 26, 2017 Type Package Title TCC: Differential expression analysis for tag count data with robust normalization strategies Version 1.16.0 Author Jianqiang Sun, Tomoaki Nishiyama, Kentaro Shimizu, and Koji Kadota Maintainer Jianqiang Sun , Tomoaki Nishiyama Description This package provides a series of functions for performing dif...
متن کاملTitle Tcc: Differential Expression Analysis for Tag Count Data with Robust Normalization Strategies
December 22, 2016 Type Package Title TCC: Differential expression analysis for tag count data with robust normalization strategies Version 1.14.0 Author Jianqiang Sun, Tomoaki Nishiyama, Kentaro Shimizu, and Koji Kadota Maintainer Jianqiang Sun , Tomoaki Nishiyama Description This package provides a series of functions for performing ...
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ژورنال
عنوان ژورنال: Bioinformatics and Biology Insights
سال: 2019
ISSN: 1177-9322,1177-9322
DOI: 10.1177/1177932219860817